SIMPONI ARIA^® is a prescription medication used to treat moderate to severe rheumatoid arthritis (RA) in adults, used in combination with methotrexate; active psoriatic arthritis (PsA) in people 2 years of age and older; active ankylosing spondylitis (AS) in adults and active polyarticular juvenile idiopathic arthritis (pJIA) in people 2 years of age or older.