Learn About SIMPONI ARIA® (golimumab)

30-MINUTE INFUSION? LEARN MORE, RIGHT THIS WAY.

SIMPONI ARIA^® (golimumab) is a biologic treatment given by intravenous infusion, also known as an IV. Your treatment starts with a 30-minute infusion, followed by a second 30-minute infusion 4 weeks later. Then you’ll receive your infusions every 8 weeks—that’s as few as 6 times a year. The infusion is given through a needle placed in your vein, usually in your arm.

RESULTS WITH SIMPONI ARIA^®

Please select a condition to learn more about SIMPONI ARIA^® results in medical studies.

Results for moderate to severe rheumatoid arthritis

In a medical study, 59% of RA patients treated with SIMPONI ARIA^® in combination with methotrexate (MTX) had a 20% improvement in symptoms of RA (joint pain, stiffness, and swelling) at 14 weeks, compared to 25% of patients treated with MTX alone.

results for moderate to severe rheumatoid arthritis reading help stop further joint damage at 24 weeks

71% of patients treated with SIMPONI ARIA^® in combination with methotrexate had no further joint damage as seen on X-ray at 24 weeks (compared to 57% of patients taking methotrexate alone).

Results for active psoriatic arthritis

In a medical study, 75% of patients treated with SIMPONI ARIA^® had a 20% improvement in symptoms of PsA (joint pain, stiffness, and swelling) at 14 weeks, compared to 22% of patients treated with placebo.

results for active psoriatic arthritis reading help stop further joint damage at 24 weeks

72% of patients treated with SIMPONI ARIA^® had no further joint damage as seen on X-ray at 24 weeks (compared to 43% of patients treated with placebo).

results for active psoriatic arthritis reading help improve skin symptoms at 14 weeks

59% of patients treated with SIMPONI ARIA^® noticed 75% improvement in skin symptoms of PsA (plaque thickness, redness, and scaling) at 14 weeks, compared to 14% of patients treated with placebo. SIMPONI ARIA^® has not been studied in and is not approved for plaque psoriasis.

72% of patients treated with SIMPONI ARIA^® had no further joint damage as seen on X-ray at 24 weeks (compared to 43% of patients treated with placebo).

Results for active ankylosing spondylitis

results for active ankylosing reading proven to help the relieve the symptoms of active AS

In a medical study, SIMPONI ARIA^® was proven to reduce the symptoms of active AS, including back pain and morning stiffness. 73% of patients treated with SIMPONI ARIA^® noticed a 20% improvement at 16 weeks, compared to 26% of patients treated with placebo.

Individual results may vary.

SERIOUS AND COMMON SIDE EFFECTS WITH SIMPONI ARIA^®

Serious side effects

SIMPONI ARIA^® (golimumab) can lower your ability to fight infections. Serious and sometimes fatal events may occur. There have been reports of serious infections including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that have spread throughout the body. Other possible serious side effects may include lymphoma, a rare and fatal cancer called hepatosplenic T-cell lymphoma, skin cancer, other cancers, hepatitis B, heart failure, nervous system problems, lupus-like symptoms, or allergic reactions.

To learn more about these and other risks, please read the Important Safety Information and Medication Guide for SIMPONI ARIA^®, and talk with your doctor.

Common side effects

The most common side effects of SIMPONI ARIA^® include:

upper respiratory infection (runny
nose, sore throat, and hoarseness or
laryngitis)
abnormal liver tests
decreased blood cells that fight infection
viral infections, such as flu and cold
sores in the mouth
bronchitis
high blood pressure
rash

To learn more about these and other risks, please read the Important Safety Information and Medication Guide for SIMPONI ARIA^®, and talk with your doctor.

DISCUSSING SIMPONI ARIA^® WITH YOUR DOCTOR

The only way to find out if SIMPONI ARIA^® is right for you is to have an open and honest conversation with your doctor about the symptoms you’re experiencing.

If you’d like some help getting that talk started, choose one of the discussion guides below:

SIMPONI ARIA^® (golimumab) is a prescription medicine. SIMPONI ARIA^® can lower your ability to fight infections. There are reports of serious infections caused by bacteria, fungi, or viruses that have spread throughout the body, including tuberculosis (TB) and histoplasmosis. Some of these infections have been fatal. Your doctor will test you for TB before starting SIMPONI ARIA^® and will closely monitor you for signs of TB during treatment. Tell your doctor if you have been in close contact with people with TB. Tell your doctor if you have been in a region (such as the Ohio and Mississippi River Valleys and the Southwest) where certain fungal infections like histoplasmosis or coccidioidomycosis are common.

You should not receive SIMPONI ARIA^® if you have any kind of infection. Tell your doctor if you are prone to or have a history of infections or have diabetes, HIV or a weak immune system. You should also tell your doctor if you are currently being treated for an infection or if you have or develop any signs of an infection such as:

fever, sweat, or chills
muscle aches
cough
shortness of breath
blood in phlegm
weight loss
warm, red, or painful skin or sores on your body
diarrhea or stomach pain
burning when you urinate or urinate more than normal
feel very tired

Your doctor will examine you for TB and perform a test to see if you have TB. If your doctor feels that you are at risk for TB, you may be treated with medicine for TB before you begin treatment with SIMPONI ARIA^® and during treatment with SIMPONI ARIA^®. Even if your TB test is negative, your doctor should carefully monitor you for TB infections while you are taking SIMPONI ARIA^®. People who had a negative TB skin test before receiving SIMPONI ARIA^® have developed active TB. Tell your doctor if you have any of the following symptoms while taking or after taking SIMPONI ARIA^®:

cough that does not go away
low grade fever
weight loss
loss of body fat and muscle (wasting)

Unusual cancers have been reported in children and teenage patients taking Tumor Necrosis Factor (TNF)-blocker medicines. For children and adults receiving TNF blockers, including SIMPONI ARIA^®, the chances for getting lymphoma or other cancers may increase. Hepatosplenic T-cell lymphoma, a rare and fatal lymphoma, has occurred mostly in teenage or young adult males with Crohn’s disease or ulcerative colitis who were taking a TNF blocker with azathioprine or 6-mercaptopurine. You should tell your doctor if you have had or develop lymphoma or other cancers.

Some people treated with SIMPONI ARIA^® developed skin cancer. Tell your doctor if any changes in the appearance of your skin or growths on your skin occur during or after your treatment with SIMPONI ARIA^®. Your doctor should periodically examine your skin, especially if you have a history of skin cancer.

Tell your doctor about all the medications you take including ORENCIA^® (abatacept), KINERET^® (anakinra), ACTEMRA^® (tocilizumab), RITUXAN^® (rituximab), or another TNF blocker, or if you are scheduled to or recently received a vaccine. People receiving SIMPONI ARIA^® should not receive live vaccines or treatment with a weakened bacteria (such as BCG for bladder cancer).

Reactivation of hepatitis B virus has been reported in patients who are carriers of this virus and are receiving TNF-blocker medicines, such as SIMPONI ARIA^®. Some of these cases have been fatal. Your doctor should do blood tests before and after you start treatment with SIMPONI ARIA^®. Tell your doctor if you know or think you may be a carrier of hepatitis B virus or if you experience signs of hepatitis B infection, such as:

feel very tired
dark urine
skin or eyes look yellow
little or no appetite
vomiting
muscle aches
clay-colored bowel movements
fever
chills
stomach discomfort
skin rash

Heart failure can occur or get worse in people who use TNF blockers, including SIMPONI ARIA^®. If you develop new or worsening heart failure with SIMPONI ARIA^®, you may need treatment in a hospital, and it may result in death. Your doctor will closely monitor you if you have heart failure. Tell your doctor right away if you get new or worsening symptoms of heart failure like shortness of breath, swelling of your lower legs or feet, or sudden weight gain.

Rarely, people using TNF blockers, including SIMPONI ARIA^®, can have nervous system problems such as multiple sclerosis or Guillain-Barré syndrome. Tell your doctor right away if you have symptoms like vision changes, weakness in your arms or legs, or numbness or tingling in any part of your body.

Rarely, people using TNF blockers have developed lupus-like symptoms. Tell your doctor if you have any symptoms such as a rash on your cheeks or other parts of the body, sensitivity to the sun, new joint or muscle pain, becoming very tired, chest pain or shortness of breath, or swelling of the feet, ankles or legs.

Serious liver problems can happen in people using TNF blockers, including SIMPONI ARIA^®. Contact your doctor immediately if you develop symptoms such as feeling very tired, skin or eyes look yellow, poor appetite or vomiting, or pain on the right side of your stomach.

Low blood counts have been seen with people using TNF blockers, including SIMPONI ARIA^®. If this occurs, your body may not make enough blood cells to help fight infections or help stop bleeding. Your doctor will check your blood counts before and during treatment. Tell your doctor if you have signs such as fever, bruising, bleeding easily, or paleness.

Allergic reactions can happen in people who use TNF-blocker medicines, including SIMPONI ARIA^®. Tell your doctor if you have any symptoms of an allergic reaction while receiving SIMPONI ARIA^® such as hives, swollen face, breathing trouble, or chest pain. Some reactions can be serious and life-threatening.

Tell your doctor if you have psoriasis.

Tell your doctor if you are pregnant, planning to become pregnant, are breastfeeding, or plan to breastfeed, or have a baby and received SIMPONI ARIA^® during pregnancy. Tell your baby’s doctor before your baby receives any vaccine because of an increased risk of infection for up to 6 months after birth.

The most common side effects of SIMPONI ARIA^® include: upper respiratory infection, abnormal liver tests, decreased blood cells that fight infection, viral infections, bronchitis, high blood pressure, and rash.

Please read the full Prescribing Information and Medication Guide for SIMPONI ARIA^® and discuss any questions you have with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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Ask your doctor today if SIMPONI ARIA^® may be right for you.

30-MINUTE INFUSION? LEARN MORE, RIGHT THIS WAY.