Learn about different medications used to treat RA

While there is no cure for rheumatoid arthritis (RA), there are treatments that can help relieve the pain, stiffness, and swelling caused by the condition. Some of the typical treatment options your doctor may consider are described below. It’s important to talk to your rheumatologist to determine which treatment option is right for you.


Often prescribed by doctors when RA first starts, nonsteroidal anti-inflammatory drugs (NSAIDs) help reduce pain, stiffness, and swelling, although they don’t stop further joint damage. Many NSAIDs, like ibuprofen (such as Motrin®* and Advil®*) and naproxen (such as Aleve®*) are available at drug stores without a prescription. Others, like Celebrex®*, require a prescription. Over time, many people find that NSAIDs may not be enough to provide the symptom relief they require.

*Indicated trademarks are the registered trademarks of their respective owners.


Your doctor may have prescribed a medicine called a DMARD (disease-modifying antirheumatic drug) to help treat your RA. Methotrexate is a commonly prescribed DMARD for the treatment of RA. While many people are helped by methotrexate, for others, it isn’t enough. Your doctor may combine methotrexate with other medications to help relieve your symptoms and help treat your RA.


Some biologic medications help treat moderate to severe RA by reducing the inflammation or swelling caused by the disease. Biologics are usually prescribed for people whose symptoms have not fully responded to DMARDs, such as methotrexate. Doctors have found that when methotrexate is combined with some anti-TNF biologic treatments, such as SIMPONI ARIA®, the 2 medications working together can be helpful in the treatment of symptoms of moderate to severe RA and in helping to stop further joint damage.

Please read the full Prescribing Information including Boxed Warnings, and Medication Guide for SIMPONI ARIA®, and discuss any questions with your doctor.

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