SIMPONI ARIA® side effects and Important Safety Information

Important considerations

If your current treatment is not providing the relief you need, your doctor may suggest starting you on a biologic medication, such as SIMPONI ARIA®. It’s only natural to have questions and concerns about starting on a biologic medication.

Here are some important things you should know about treatment with SIMPONI ARIA®:

SIMPONI ARIA® is a biologic treatment for adults with:

  • Moderate to severe rheumatoid arthritis (RA), used in combination with methotrexate. Methotrexate is taken as directed
  • Active psoriatic arthritis (PsA)
  • Active ankylosing spondylitis (AS)

Only your doctor can decide if SIMPONI ARIA® is right for you. SIMPONI ARIA® can cause serious side effects. Please read the Medication Guide for SIMPONI ARIA® and discuss any symptoms or questions with your doctor.

SIMPONI ARIA® (golimumab) can lower your ability to fight infections. Serious and sometimes fatal events may occur. There have been reports of serious infections including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses that have spread throughout the body. Other possible serious side effects may include lymphoma, a rare and fatal cancer called hepatosplenic T-cell lymphoma, skin cancer, other cancers, hepatitis B, heart failure, nervous system problems, lupus-like symptoms, or allergic reactions. To learn more about these and other risks, please read the Important Safety Information and Medication Guide, and talk with your doctor.

The most common SIMPONI ARIA® side effects include:

  • Upper respiratory infection (runny nose, sore throat, and hoarseness or laryngitis)
  • Abnormal liver tests
  • Decreased blood cells that fight infection
  • Viral infections such as flu and cold sores in the mouth
  • Bronchitis
  • High blood pressure
  • Rash

To learn more about these and other risks, please read the Important Safety Information and Medication Guide for SIMPONI ARIA®, and talk with your doctor.

SIMPONI ARIA® is prepared and given by your healthcare professional as a 30-minute infusion every 8 weeks after 2 starter doses, given 4 weeks apart. The infusion is given through a needle placed in your vein, usually in your arm.

Watch a video describing the infusion process by clicking here.

After 2 starter doses, 4 weeks apart, SIMPONI ARIA® is given by a healthcare professional once every 8 weeks—that’s as few as 6 infusions a year.

If you forget or miss an infusion appointment, make another appointment as soon as possible.

While taking SIMPONI ARIA®, you may continue to use other medications that help treat your condition, such as nonsteroidal anti-inflammatory drugs (NSAIDs), prescription steroids, and pain relief medicines, as recommended by your doctor.

Be sure to tell your doctor about all the medications you are taking before starting SIMPONI ARIA®, or if you are scheduled to or recently received a vaccine. People receiving SIMPONI ARIA® should not receive live vaccines or treatment with a weakened bacteria (such as BCG for bladder cancer). Especially tell your doctor if you use ORENCIA®* (abatacept) or KINERET®* (anakinra). You should not receive SIMPONI ARIA® while you are also taking ORENCIA®* (abatacept) or KINERET®* (anakinra). Tell your doctor if you are taking other TNF-blocker medicines, including HUMIRA®* (adalimumab), ENBREL®* (etanercept), or CIMZIA®* (certolizumab pegol), or if you are taking RITUXAN®* (rituximab) or ACTEMRA®* (tocilizumab). Ask your doctor if you are not sure if your medicine is one listed above.

*Indicated trademarks are the registered trademarks of their respective owners.

Have more questions?

Janssen CarePath is here to help with medication cost support and treatment support.

For a Janssen CarePath Care Coordinator: 
Weekdays, 8:00 am-8:00 pm ET 

For Janssen Nurse Support: 
Weekdays, 9:00 am-8:00 pm ET

At all other times, a nurse will typically return your call within 15 minutes.*

*The nurse program is limited to education for patients about their Janssen therapy, its administration, and/or their disease, and is not intended to provide medical advice, replace a treatment plan from the patient's doctor or nurse, or provide case-management services.

Spanish-speaking support

Janssen CarePath offers Spanish-speaking Care Coordinators. Janssen Nurse Support offers assistance in Spanish.